Cognitive fusion as a candidate psychological vulnerability factor for psychosis: An experimental study of acute ∆9-tetrahydrocannabinol (THC) intoxication

Heavy cannabis use is associated with an increased risk of psychosis. However, the psychological mechanisms involved, and interactions established factors for cannabis-related psychosis, remain unclear. This study examined role cognitive fusion, a candidate vulnerability factor during acute THC intoxication, interaction key – developmental trauma schizotypy. Twenty general population cannabis-using participants were administered or placebo in within-participants, double-blinded randomised study. Developmental trauma, schizotypy fusion all psychotic experiences intoxication. Cognitive accounted those high may be mechanism by which increase psychosis from use. initial limited small sample correlational design; larger scale mediation now needed to support causal argument. The findings have implications treatments identifying at Psychological interventions that target more effective than generic approaches. People prone particularly history schizotypy, higher